Thursday, July 4, 2013

And , OsteoArthritis So Darned Tough to Treat?

Recent research efforts upon both Northwestern University in Chicago and the University of Pittsburgh Healthcare have described work on the use of a new nanofiber gel providing cartilage growth in important joints.

The material is injected relating to the damaged joint and stimulates bone marrow stem cells to bake natural cartilage.

The nanofibers allow root cells from bone marrow to get cartilage containing type II bovine collagen and repair a scarred joint.

Type II collagen is likely major protein component involving articular cartilage, the gristle that shelves the ends of long bones within joint.

This is distinctly completely at odds with the Type I collagen produced which result from another procedure used to make sure they heal cartilage damage called microfracture. Microfracture is cosmetic plastic surgery where small holes are drilled into the bone beneath the metropolis of cartilage damage. This leads bleeding from the calcaneus marrow.

Ostensibly, stem cells the actual marrow create new flexible material.

Microfracture causes the output of cartilage having predominately model I collagen. Type I collagen is likely type found most commonly in scar tissue formation.

Type II collagen will be weaker than Type I collagen and in all likelihood does not hold up as well. This may be one reasons microfracture surgery has had trouble as first thought.

Another type of selection process called autologous chondrocyte transplantation is used. In this selection process, cartilage is harvested from a non-weight-bearing section of the joint. The cartilage will be specially treated in a laboratory to guarantee that individual cartilage cells copy. The cartilage cells are then put in the present joint under a gently flap of tissue that is sewn into place. Recovery is long and individuals cartilage produced also appears to be contain mostly Type CAN I collagen.

Mosaicplasty where multiple cartilage plugs are installed in the cartilage defect is used. Results are partnered.

Stem cell Treatment maintain a pool of appeal of being paler invasive and requiring less outages. However, controlled data is most effective nonexistent. Supportive evidence covers case studies and browse numbers.

One issue that has plagued researchers and clinicians alike maybe mechanical forces present within weight-bearing joints such as the hip and knee.

When asked his opinion to get the nanofiber issue, Dr. Kevin Arnold, a Chicago-based rheumatologist detailed, "This isn't the in the beginning 'cartilage growth stimulator'... and and also the last. There's no way that will not cartilage regrows on the top of medial femoral condyle (of the knee) the mechanical correction accompanying the "regrowth". The shear compression forces inside medial compartment are dominant... and would quickly chewing any flimsy cartilage surface start to grow on the top of condyle. "

Dr. Nathan Wei, a rheumatologist dedicated in stem cell Treatment within OsteoArthritis, concurs with Doctor. Arnold to a teather. He states, "The impact loading units on weight-bearing joints such as the knee and hip are one thing to contend with but with the hip there is an added stress of rotational movement and the knee there finish gliding and rotational forces to handle as well. "

He states though, "Animal models have exhibited that stem cell procedures execute. And while human information and facts is sparse, early evidence the fishing rod further investigation... I do agree that mechanical forces need to be dealt with through various means place in allow stem cells to 'take'. We are currently seeking address this issue. Our results at the moment though are very encouraging. "


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